منابع مشابه
HIV-1 evolution and disease progression.
REFERENCES AND NOTES se that destroys the host. Thus, within a particular host, diversity is driven by the collective sum of all the selective forces acting on the HIV-1 quasispecies virus population, rather than a specific immune parameter by or in itself (4). The theory predicts two possible outcomes. First, infected individuals with diversity higher than their individual specific threshold l...
متن کاملDynamic Correlation between Intrahost HIV-1 Quasispecies Evolution and Disease Progression
Quantifying the dynamics of intrahost HIV-1 sequence evolution is one means of uncovering information about the interaction between HIV-1 and the host immune system. In the chronic phase of infection, common dynamics of sequence divergence and diversity have been reported. We developed an HIV-1 sequence evolution model that simulated the effects of mutation and fitness of sequence variants. The...
متن کاملHIV-1 Fitness: Implications for Drug Resistance, Disease Progression, and Global Epidemic Evolution
In the past five years, the HIV research field has shown renewed interest in the replicative capacity of human immunodeficiency virus type 1 (HIV-1) due to the potential impact of ex vivo viral fitness on population size (viral load), drug resistance, and disease progression. For example, studies on HIV-1 fitness of drug-resistant mutants under different selective pressures have led to a better...
متن کاملBreastfeeding and maternal HIV-1 disease progression and mortality.
OBJECTIVE To examine the association between breastfeeding and disease progression among HIV-infected women in Dar es Salaam, Tanzania. DESIGN AND METHODS Cohort study design with Cox proportional hazards models. RESULTS The relative risk of death comparing women who recently had been breastfeeding to those who were not breastfeeding was 0.47 (95% confidence interval, 0.18-1.20). Neither br...
متن کاملHormonal contraceptive use and risk of HIV-1 disease progression.
BACKGROUND For HIV-1-infected women, hormonal contraception prevents unintended pregnancy, excess maternal morbidity, and vertical HIV-1 transmission. Hormonal contraceptives are widely used but their effects on HIV-1 disease progression are unclear. METHODS In a prospective study among 2269 chronically HIV-1-infected women from seven countries in eastern and southern Africa and with enrollme...
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ژورنال
عنوان ژورنال: Science
سال: 1996
ISSN: 0036-8075,1095-9203
DOI: 10.1126/science.274.5289.1008